Er immunotherapy.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript4. Antibody-based immunotherapiesAntibody-based therapy has emerged as an integral part of effective treatments for a number of malignancies. In the last decade, monoclonal antibodies have become major therapeutic vehicles in the treatment of malignant and nonmalignant diseases. The success of immunebased tr
Er immunotherapy.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript4. Antibody-based immunotherapiesAntibody-based therapy has emerged as an integral part of effective treatments for a number of malignancies. In the last decade, monoclonal antibodies have become major therapeutic vehicles in the treatment of malignant and nonmalignant diseases. The success of immunebased tr
Duction. However, the physiological mechanisms that drive this system to generate bradykinin remain elusive. The plasma contact system consists of the two proteases, factor XII (FXII) and plasma prekallikrein (pro-pKal), and their non-enzymatic cofactor high molecular weight kininogen (HK). These coagulation factors spontaneously activate in the presence of negatively charged surfaces, which [as p
Duction. However, the physiological mechanisms that drive this system to generate bradykinin remain elusive. The plasma contact system consists of the two proteases, factor XII (FXII) and plasma prekallikrein (pro-pKal), and their non-enzymatic cofactor high molecular weight kininogen (HK). These coagulation factors spontaneously activate in the presence of negatively charged surfaces, which [as p
Ten days. The delayed ammonia burst accompanied a delayed increase in pH, which both preceded exponential growth of the mutant. Thus, the phenotype of the ompATb operon mutant consists of severe delays in ammonia secretion, medium pH neutralization, and growth compared to wt M. tuberculosis. However, all changes in these parameters after onset were similar in magnitude and kinetics. Expression of
Ten days. The delayed ammonia burst accompanied a delayed increase in pH, which both preceded exponential growth of the mutant. Thus, the phenotype of the ompATb operon mutant consists of severe delays in ammonia secretion, medium pH neutralization, and growth compared to wt M. tuberculosis. However, all changes in these parameters after onset were similar in magnitude and kinetics. Expression of