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Over 4 weeks) at a dose volume of 0.32 mL/kg. Three female minipigs received sterile physiological saline and were used as concurrent controls. Reversibility of findings was assessed after a 4-week dosing-free period in two additional control and two high-dose minipigs. RTR2996--Three minipigs were dosed intravenously at 5, 15, and 45 mg/kg RTR2996 for 5 min at 2 mL/kg every other day for 15 days.

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