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<title>2 Learn How / scent8tomato / Upvoted</title>
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<pubDate>Wed, 28 Jun 2023 16:06:17 +0000</pubDate>
<language>en</language>
<item>
	<title><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target]]></title>
	<link>http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-7</link>
	<source url="http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-7"><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target]]></source>
	<description><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad  ]]></description>
	<pubDate>Wed, 28 Jun 2023 16:06:17 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-7</guid>
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<item>
	<title><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></title>
	<link>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-9</link>
	<source url="http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-9"><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></source>
	<description><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in HIV-1-infected individuals; however, no effect on plasma viral loads was observed [13]. Further examination revealed that doses of sCD4 that were significantly higher than those achieved in the clinical trial were required to neutralize primary clinical isolates of HIV-1, in contrast to the relatively sensitive, laboratory-adapte ]]></description>
	<pubDate>Tue, 27 Jun 2023 18:15:20 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-9</guid>
</item>

<item>
	<title><![CDATA[Amic changes in conformation and function of the HIV-1 envelope glycoproteins]]></title>
	<link>http://2learnhow.com/story.php?title=amic-changes-in-conformation-and-function-of-the-hiv-1-envelope-glycoproteins-4</link>
	<source url="http://2learnhow.com/story.php?title=amic-changes-in-conformation-and-function-of-the-hiv-1-envelope-glycoproteins-4"><![CDATA[Amic changes in conformation and function of the HIV-1 envelope glycoproteins]]></source>
	<description><![CDATA[Amic changes in conformation and function of the HIV-1 envelope glycoproteins, immediately after engagement of the activating molecules. Using these tools, we found that SCMs inactivate envelope glycoprotein function by an activation-triggered inhibition process, through induction of a metastable activated state.Materials and Methods Reagents and AntibodiesFour-domain sCD4 (molecular weight 50 kDa ]]></description>
	<pubDate>Mon, 26 Jun 2023 15:19:40 +0000</pubDate>
	<author>scent8tomato</author>
	<category></category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=amic-changes-in-conformation-and-function-of-the-hiv-1-envelope-glycoproteins-4</guid>
</item>

<item>
	<title><![CDATA[ErcialNoDerivs 3.0 Unported License. The images or other third party material in]]></title>
	<link>http://2learnhow.com/story.php?title=ercialnoderivs-3-0-unported-license-the-images-or-other-third-party-material-in-4</link>
	<source url="http://2learnhow.com/story.php?title=ercialnoderivs-3-0-unported-license-the-images-or-other-third-party-material-in-4"><![CDATA[ErcialNoDerivs 3.0 Unported License. The images or other third party material in]]></source>
	<description><![CDATA[ErcialNoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://cr ]]></description>
	<pubDate>Mon, 26 Jun 2023 14:46:34 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=ercialnoderivs-3-0-unported-license-the-images-or-other-third-party-material-in-4</guid>
</item>

<item>
	<title><![CDATA[Effects of inflammation on health during chronic HIV infection. Immunity 2013; 39: 633?45. 55. Kuller]]></title>
	<link>http://2learnhow.com/story.php?title=effects-of-inflammation-on-health-during-chronic-hiv-infection-immunity-2013-39-63345-55-kuller-7</link>
	<source url="http://2learnhow.com/story.php?title=effects-of-inflammation-on-health-during-chronic-hiv-infection-immunity-2013-39-63345-55-kuller-7"><![CDATA[Effects of inflammation on health during chronic HIV infection. Immunity 2013; 39: 633?45. 55. Kuller]]></source>
	<description><![CDATA[Effects of inflammation on health during chronic HIV infection. Immunity 2013; 39: 633?45. 55. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5: e203. 56. Neuhaus J, Jacobs Jr DR, Baker JV, Calmy A, Duprez D, La Rosa A et al. Markers of inflammation, coagulation, and renal func ]]></description>
	<pubDate>Sun, 25 Jun 2023 14:57:24 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=effects-of-inflammation-on-health-during-chronic-hiv-infection-immunity-2013-39-63345-55-kuller-7</guid>
</item>

<item>
	<title><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></title>
	<link>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-5</link>
	<source url="http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-5"><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></source>
	<description><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in HIV-1-infected individuals; however, no effect on plasma viral loads was observed [13]. Further examination revealed that doses of sCD4 that were significantly higher than those achieved in the clinical trial were required to neutralize primary clinical isolates of HIV-1, in contrast to the relatively sensitive, laboratory-adapte ]]></description>
	<pubDate>Sun, 25 Jun 2023 14:41:35 +0000</pubDate>
	<author>scent8tomato</author>
	<category></category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-5</guid>
</item>

<item>
	<title><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></title>
	<link>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-5</link>
	<source url="http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-5"><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></source>
	<description><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in HIV-1-infected individuals; however, no effect on plasma viral loads was observed [13]. Further examination revealed that doses of sCD4 that were significantly higher than those achieved in the clinical trial were required to neutralize primary clinical isolates of HIV-1, in contrast to the relatively sensitive, laboratory-adapte ]]></description>
	<pubDate>Sun, 25 Jun 2023 14:40:46 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-5</guid>
</item>

<item>
	<title><![CDATA[Port, we show that soluble mimics of CD4 inhibit HIV-1 infection]]></title>
	<link>http://2learnhow.com/story.php?title=port-we-show-that-soluble-mimics-of-cd4-inhibit-hiv-1-infection-7</link>
	<source url="http://2learnhow.com/story.php?title=port-we-show-that-soluble-mimics-of-cd4-inhibit-hiv-1-infection-7"><![CDATA[Port, we show that soluble mimics of CD4 inhibit HIV-1 infection]]></source>
	<description><![CDATA[Port, we show that soluble mimics of CD4 inhibit HIV-1 infection by prematurely triggering the viral envelope glycoproteins. The unstable activated state of the virus lasts only a few minutes, after which the virus loses the ability to infect cells. This novel strategy for inhibition may be generally applicable to other viruses besides HIV-1, some of which are also activated by binding to their re ]]></description>
	<pubDate>Tue, 20 Jun 2023 14:39:18 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=port-we-show-that-soluble-mimics-of-cd4-inhibit-hiv-1-infection-7</guid>
</item>

<item>
	<title><![CDATA[Port, we show that soluble mimics of CD4 inhibit HIV-1 infection]]></title>
	<link>http://2learnhow.com/story.php?title=port-we-show-that-soluble-mimics-of-cd4-inhibit-hiv-1-infection-5</link>
	<source url="http://2learnhow.com/story.php?title=port-we-show-that-soluble-mimics-of-cd4-inhibit-hiv-1-infection-5"><![CDATA[Port, we show that soluble mimics of CD4 inhibit HIV-1 infection]]></source>
	<description><![CDATA[Port, we show that soluble mimics of CD4 inhibit HIV-1 infection by prematurely triggering the viral envelope glycoproteins. The unstable activated state of the virus lasts only a few minutes, after which the virus loses the ability to infect cells. This novel strategy for inhibition may be generally applicable to other viruses besides HIV-1, some of which are also activated by binding to their re ]]></description>
	<pubDate>Tue, 20 Jun 2023 14:38:36 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=port-we-show-that-soluble-mimics-of-cd4-inhibit-hiv-1-infection-5</guid>
</item>

<item>
	<title><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></title>
	<link>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-9</link>
	<source url="http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-9"><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></source>
	<description><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in HIV-1-infected individuals; however, no effect on plasma viral loads was observed [13]. Further examination revealed that doses of sCD4 that were significantly higher than those achieved in the clinical trial were required to neutralize primary clinical isolates of HIV-1, in contrast to the relatively sensitive, laboratory-adapte ]]></description>
	<pubDate>Fri, 16 Jun 2023 15:14:44 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in-9</guid>
</item>

<item>
	<title><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target]]></title>
	<link>http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-8</link>
	<source url="http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-8"><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target]]></source>
	<description><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad  ]]></description>
	<pubDate>Fri, 16 Jun 2023 14:55:18 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-8</guid>
</item>

<item>
	<title><![CDATA[Effects of inflammation on health during chronic HIV infection. Immunity 2013; 39: 633?45. 55. Kuller]]></title>
	<link>http://2learnhow.com/story.php?title=effects-of-inflammation-on-health-during-chronic-hiv-infection-immunity-2013-39-63345-55-kuller-6</link>
	<source url="http://2learnhow.com/story.php?title=effects-of-inflammation-on-health-during-chronic-hiv-infection-immunity-2013-39-63345-55-kuller-6"><![CDATA[Effects of inflammation on health during chronic HIV infection. Immunity 2013; 39: 633?45. 55. Kuller]]></source>
	<description><![CDATA[Effects of inflammation on health during chronic HIV infection. Immunity 2013; 39: 633?45. 55. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5: e203. 56. Neuhaus J, Jacobs Jr DR, Baker JV, Calmy A, Duprez D, La Rosa A et al. Markers of inflammation, coagulation, and renal func ]]></description>
	<pubDate>Wed, 14 Jun 2023 16:13:47 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=effects-of-inflammation-on-health-during-chronic-hiv-infection-immunity-2013-39-63345-55-kuller-6</guid>
</item>

<item>
	<title><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target]]></title>
	<link>http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-7</link>
	<source url="http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-7"><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target]]></source>
	<description><![CDATA[Coproteins [1]. Binding of gp120 to the receptor, CD4, on the target cell surface induces major conformational changes in the envelope glycoproteins [2]. These changes allow gp120 to bind the viral coreceptor, either CXCR4 or CCR5 [3?]. CD4 binding also induces the formation of a gp41 pre-hairpin intermediate, in which three hydrophobic grooves on the surface of a coiled coil formed by the heptad  ]]></description>
	<pubDate>Thu, 08 Jun 2023 18:46:01 +0000</pubDate>
	<author>scent8tomato</author>
	<category></category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=coproteins-1-binding-of-gp120-to-the-receptor-cd4-on-the-target-7</guid>
</item>

<item>
	<title><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></title>
	<link>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in</link>
	<source url="http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in"><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in]]></source>
	<description><![CDATA[Infection in vitro, this protein was tested for clinical efficacy in HIV-1-infected individuals; however, no effect on plasma viral loads was observed [13]. Further examination revealed that doses of sCD4 that were significantly higher than those achieved in the clinical trial were required to neutralize primary clinical isolates of HIV-1, in contrast to the relatively sensitive, laboratory-adapte ]]></description>
	<pubDate>Tue, 06 Jun 2023 07:23:49 +0000</pubDate>
	<author>scent8tomato</author>
	<category>News</category>
	<votes>1</votes>
	<guid>http://2learnhow.com/story.php?title=infection-in-vitro-this-protein-was-tested-for-clinical-efficacy-in</guid>
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