http://2learnhow.com/story.php?title=duction-however-the-physiological-mechanisms-that-drive-this-system-to-generate Duction. However, the physiological mechanisms that drive this system to generate bradykinin remain elusive. The plasma contact system consists of the two proteases, factor XII (FXII) and plasma prekallikrein (pro-pKal), and their non-enzymatic cofactor high molecular weight kininogen (HK). These coagulation factors spontaneously activate in the presence of negatively charged surfaces, which [as p Wed, 26 Jan 2022 08:25:18 UTC en