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No direct proof in an ALS model so far, a number of them may have a advantageous impact around the NMJs and their regeneration, for example G-CSF (Pan et al., 2009), IGF-1 (Apel et al., 2009) and EPO (Toth et al., 2008). The available mode of action and animal model data should then be reviewed by an expert panel with all the aim to choose no matter whether the evidence package as a whole is suffi
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