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3 years ago). While amounts of macrophages diminished with EPO treatment in 14?days, amounts of microglia more than doubled simply by practically half a dozen occasions in accordance with figures throughout TAI?+?EPO rats at 7?days (201.30?��?73.Sixty eight vs . Thirty-four.27?��?30.Fifty nine, S
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Ases its substrates. After dissociation from Hsp70, the polypeptide chains fold into a functional three-dimensional architecture. A model has been proposed in which Hsp40 first recognizes and binds substrate polypeptides and then transfers them to Hsp70. However, in some cases, DnaK itself recognizes and binds to substrate polypeptides independent of DnaJ, as in the case of 32 (24). Because most o
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Ases its substrates. After dissociation from Hsp70, the polypeptide chains fold into a functional three-dimensional architecture. A model has been proposed in which Hsp40 first recognizes and binds substrate polypeptides and then transfers them to Hsp70. However, in some cases, DnaK itself recognizes and binds to substrate polypeptides independent of DnaJ, as in the case of 32 (24). Because most o
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Tive substrate, bacteriophage P1 RepA protein, have located DnaK- and DnaJ-binding sites in RepA (25). To gain further insight into chaperone functions in 32 degradation, we isolated many 32 mutants that are stable in vivo (26). These mutants contain one or two amino acid substitutions in the N-terminal half of Region 2.1. In this study, we examined the affinity of some mutant 32 for proteases and
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